import math import matplotlib.pyplot as plt import numpy as np from graph_tool.all import * from src import centrality from src import plot from src import fitting def degree(g, weight): # VertexPropertyMap vp = g.new_vertex_property("double") for v in g.vertices(): neighbours = g.get_all_neighbours(v) vp[v] = len(neighbours) return vp def leverage(g, weight): # VertexPropertyMap vp = g.new_vertex_property("double") for v in g.vertices(): li = 0.0 neighbours = g.get_all_neighbours(v) ki = len(neighbours) # sum for nv, props in neighbours: other_neighbours = g.get_all_neighbours(nv) kj = len(other_neighbours) li += (ki - kj) / (ki + kj) li /= ki vp[v] = li return vp def random_graph(n=5000, seed=None): """ Uniformly random point cloud generation. `n` [int] Number of points to generate. Default 5000 seems like a good starting point in point density and corresponding runtime for the subsequent calculations. @return [numpy.ndarray] Array of shape(n, 2) containing the coordinates for each point of the generated point cloud. """ if seed is None: import secrets seed = secrets.randbits(128) rng = np.random.default_rng(seed=seed) return rng.random((n, 2)), seed def random_graph_favor_border(n=3000, seed = None): if seed is None: import secrets seed = secrets.randbits(128) rng = np.random.default_rng(seed=seed) vps = np.zeros((n, 2)) for i in range(0, n): r_x = rng.random() if rng.random() > 0.5: while (r_x > 0.3 and r_x < 0.7): r_x = rng.random() r_y = rng.random() if rng.random() > 0.5: while (r_y > 0.3 and r_y < 0.7): r_y = rng.random() vps[i][0] = r_x vps[i][1] = r_y return vps, seed def random_graph_favor_center(n=3000, seed = None): if seed is None: import secrets seed = secrets.randbits(128) rng = np.random.default_rng(seed=seed) vps = np.zeros((n, 2)) for i in range(0, n): r_x = rng.random() if rng.random() > 0.7: while (r_x < 0.4 or r_x > 0.6): r_x = rng.random() r_y = rng.random() if rng.random() > 0.7: while (r_y < 0.4 or r_y > 0.6): r_y = rng.random() vps[i][0] = r_x vps[i][1] = r_y return vps, seed def spatial_graph(adata): """ Generate the spatial graph using delaunay for the given `adata`. `adata` will contain the calculated spatial graph contents in the keys adata.obsm['spatial']` in case the `adata` is created from a dataset of *squidpy*. @return [Graph] generated networkx graph from adata.obsp['spatial_distances'] """ g, pos = graph_tool.generation.triangulation(adata, type="delaunay") g.vp["pos"] = pos weight = g.new_edge_property("double") for e in g.edges(): weight[e] = math.sqrt(sum(map(abs, pos[e.source()].a - pos[e.target()].a)))**2 return g, weight def apply(g, seed, weight, convex_hull, ax, method, method_name): # calculate centrality values vp = method(g, weight=weight) vp.a = np.nan_to_num(vp.a) # correct floating point values # normalization min_val, max_val = vp.a.min(), vp.a.max() vp.a = (vp.a - min_val) / (max_val - min_val) # generate model based on convex hull and associated centrality values quantification = plot.quantification_data(g, vp, convex_hull) # optimize model's piece-wise linear function d = quantification[:, 0] C = quantification[:, 1] m_opt, c0_opt, b_opt, aic_opt = fitting.fit_piece_wise_linear(d, C) # TODO # should this be part of the plotting function itself, it should not be necessary for me to do this d_curve = np.linspace(min(d), max(d), 500) C_curve = np.piecewise( d_curve, [d_curve <= b_opt, d_curve > b_opt], [lambda x: m_opt * x + c0_opt, lambda x: m_opt * b_opt + c0_opt] ) # plot model containing modeled piece-wise linear function plot.quantification_plot(ax, quantification, d_curve, C_curve, 'Models', aic_opt) # # - Create a random point cloud and calculate a triangulation on it # - For that graph calculate the convex hull # - Draw the graph with the convex hull # - For each centrality measure # - apply centrality measure to the next axis # - Draw the corresponding resulting models into a grid # points, seed = random_graph() g, weight = spatial_graph(points) g = GraphView(g) # calculate convex hull convex_hull = centrality.convex_hull(g) # plot graph with convex_hull fig_graph, ax_graph = plt.subplots(figsize=(15, 5)) # draw without any centrality measure `vp` plot.graph_plot(fig_graph, ax_graph, g, vp, convex_hull, f"Pointcloud (seed: {seed}\n{method_name}") fig_graph.savefig("Pointcloud_graph.svg", format='svg') fig = plt.figure(figsize=(15, 10)) axs = fig.subplots(2, 4) i = 0 for ax in axs: # TODO select corresponding centrality measure method apply(g, seed, weight, convex_hull, ax, closeness, "Closeness") apply(g, seed, weight, convex_hull, ax, pagerank, "PageRank") apply(g, seed, weight, convex_hull, ax, betweeness, "Betweeness") apply(g, seed, weight, convex_hull, ax, eigenvector, "Eigenvector") apply(g, seed, weight, convex_hull, ax, katz, "Katz") # TODO to implement # - Laplacian # - Leverage # - Degree (seriously?) i += 1 fig.savefig(f"Comparison_Pointcloud.svg", format='svg')